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1

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as Novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK

Laufer, Radoslaw, Li, Sze-Wan, Liu, Yong, Ng, Grace, Lang, Yunhui, Feher, Miklos, Brokx, Richard, Beletskaya, Irina, Hodgson, Richard, Mao, Guodong, Plotnikova, Olga, Awrey, Donald E., Mason, Jacqueli

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 841 KB

english, 2016

2

Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors

Sampath-Kumar Anandan, John S. Ward, Richard D. Brokx, Mark R. Bray, Dinesh V. Patel, Xiao-Xi Xiao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 118 KB

english, 2005

3

Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors

Sampath-Kumar Anandan, John S. Ward, Richard D. Brokx, Trisha Denny, Mark R. Bray, Dinesh V. Patel, Xiao-Yi Xiao

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 139 KB

english, 2007

4

Peptide and metal ion-dependent association of isolated helix-loop-helix calcium binding domains: Studies of thrombic fragments of calmodulin

Richard D. Brokx, Hans J. Vogel

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 525 KB

english, 2000

5

Initial bronchoscopic treatment for patients with intraluminal bronchial carcinoids

Hes A.P. Brokx, Elle K. Risse, Marinus A. Paul, Katrien Grünberg, Richard P. Golding, Peter W.A. Kunst, Jan-Peter Eerenberg, Johan C. van Mourik, Pieter E. Postmus, Wolter J. Mooi, Tom G. Sutedja

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Year:

2007

Language:

english

File:

PDF, 365 KB

english, 2007

6

Designing peptide-based scaffolds as drug delivery vehicles

Richard D Brokx, Stuart K Bisland, Jean Gariépy

Journal:

Journal of Controlled Release

Year:

2002

Language:

english

File:

PDF, 823 KB

english, 2002

7

Tandem Dimerization of the Human p53 Tetramerization Domain Stabilizes a Primary Dimer Intermediate and Dramatically Enhances its Oligomeric Stability

Gregory M.K. Poon, Richard D. Brokx, Michael Sung, Jean Gariépy

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.21 MB

english, 2007

8

Backbone dynamic properties of the central linker region of calcium-calmodulin in 35% trifluoroethanol

Richard D. Brokx, Ruud M. Scheek, Aalim M. Weljie, Hans J. Vogel

Journal:

Journal of Structural Biology

Year:

2004

Language:

english

File:

PDF, 442 KB

english, 2004

9

Nuclear Magnetic Resonance-Based Dissection of a Glycosyltransferase Specificity for the Mucin MUC1 Tandem Repeat †

Brokx, Richard D., Revers, Leigh, Zhang, Qinghong, Yang, Shaoxian, Mal, Tapas K., Ikura, Mitsuhiko, Gariépy, Jean

Journal:

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

10

Characterization of an Escherichia coli Sulfite Oxidase Homologue Reveals the Role of a Conserved Active Site Cysteine in Assembly and Function †

Brokx, Stephen J., Rothery, Richard A., Zhang, Guijin, Ng, Derek P., Weiner, Joel H.

Journal:

Year:

2005

Language:

english

File:

PDF, 172 KB

english, 2005

11

Discovery of Pyrazolo[1,5- a ]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

Liu, Yong, Laufer, Radoslaw, Patel, Narendra Kumar, Ng, Grace, Sampson, Peter B., Li, Sze-Wan, Lang, Yunhui, Feher, Miklos, Brokx, Richard, Beletskaya, Irina, Hodgson, Richard, Plotnikova, Olga, Awrey

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

12

Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer

Mason, Jacqueline M., Wei, Xin, Fletcher, Graham C., Kiarash, Reza, Brokx, Richard, Hodgson, Richard, Beletskaya, Irina, Bray, Mark R., Mak, Tak W.

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.08 MB

english, 2017

13

Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

Veitch, Zachary W., Cescon, David W., Denny, Trisha, Yonemoto, Lisa-Maria, Fletcher, Graham, Brokx, Richard, Sampson, Peter, Li, Sze-Wan, Pugh, Trevor J., Bruce, Jeffrey, Bray, Mark R., Slamon, Dennis

Journal:

British Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 874 KB

english, 2019

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